Gene: TLR4 ENSG00000136869

Description

toll-like receptor 4 [Source:HGNC Symbol;Acc:11850]

Gene Synonyms

ARMD10, CD284, TLR-4, TOLL, hToll

Location

GRCh37:CM000671.1

About this gene

This gene has 4 transcripts (splice variants), 11 paralogues and is associated with 3 phenotypes.

Transcripts

Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000355622.6	TLR4-001	4844	839aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS6818	D0EWT7 K9MSZ3 O00206	NM_138557.2	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000394487.4	TLR4-002	3908	799aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		D0EWT7 K9MSZ3 O00206	NM_003266.3	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000472304.1	TLR4-003	2741	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000490685.1	TLR4-004	539	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-

Summary

Name

TLR4 (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: O00206

CCDS

This gene is a member of the Human CCDS set: CCDS6818.1

Ensembl version

ENSG00000136869.13

Other assemblies

This gene maps to 117,704,332-117,716,871 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000021046 (version 4)

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