Description
caspase 8, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1509]
Gene Synonyms
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
Location
Chromosome 2: 202,098,166-202,152,434 forward strand.
GRCh37:CM000664.1
About this gene
This gene has 21 transcripts (splice variants), 12 paralogues and is associated with 73 phenotypes.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | CCDS | UniProt Match | RefSeq | Flags |
|---|---|---|---|---|---|---|---|---|---|
| ENST00000358485.4 | CASP8-002 | 2930 | 538aa | ENSP00000351273.4 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS42798 | E7EQ01 E7ETB7 E7EVN1 Q14790 | NM_001080125.1 | A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000392259.2 | CASP8-202 | 2727 | 235aa | ENSP00000376088.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS2345 | E7EQ01 E7ETB7 E7EVN1 Q14790 | - | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000392266.3 | CASP8-203 | 2682 | 220aa | ENSP00000376094.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 E7EQ06 E7EVN1 H7BZM4 Q14790 | - | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, | |
| ENST00000323492.7 | CASP8-012 | 2650 | 464aa | ENSP00000325722.7 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS2343 | C9JB29 E7EQ01 E7EVN1 Q14790 | NM_033356.3 | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000264274.9 | CASP8-201 | 2540 | 395aa | ENSP00000264274.9 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 E7EVN1 H7C0E2 Q14790 | - | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, | |
| ENST00000264275.5 | CASP8-006 | 1906 | 496aa | ENSP00000264275.5 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS42799 | C9JB29 Q14790 | NM_001228.4 | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000432109.2 | CASP8-014 | 1629 | 479aa | ENSP00000412523.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS2342 | E7EQ01 E7ETB7 E7EVN1 Q14790 | NM_033355.3 | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000392263.2 | CASP8-009 | 1627 | 464aa | ENSP00000376091.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | C9JB29 E7EQ01 E7EVN1 Q14790 | NM_001080124.1 | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000444430.2 | CASP8-017 | 1275 | 258aa | ENSP00000394434.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | H7C0E2 | - | 5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete, | |
| ENST00000392258.3 | CASP8-004 | 1060 | 235aa | ENSP00000376087.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS2345 | E7EQ01 E7ETB7 E7EVN1 Q14790 | NM_033358.3 | A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, |
| ENST00000429881.1 | CASP8-026 | 717 | 116aa | ENSP00000390641.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000447616.1 | CASP8-010 | 707 | 209aa | ENSP00000388306.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 E7EQ06 E7EVN1 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000450491.1 | CASP8-020 | 686 | 149aa | ENSP00000391709.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | C9JB29 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000413726.1 | CASP8-023 | 658 | 198aa | ENSP00000397528.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 E7ETB7 E7EVN1 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000440732.1 | CASP8-021 | 592 | 124aa | ENSP00000396869.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EQ01 E7EVN1 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000424461.1 | CASP8-016 | 308 | 83aa | ENSP00000390346.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | H7BZM4 | - | 5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete, | |
| ENST00000437283.1 | CASP8-001 | 777 | 58aa | ENSP00000407378.1 | Nonsense mediated decay | F8WF39 | - | - | |
| ENST00000490682.1 | CASP8-008 | 2911 | No protein | - | Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript | - | - | - | |
| ENST00000490412.1 | CASP8-011 | 230 | No protein | - | Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript | - | - | - | |
| ENST00000339403.6 | CASP8-007 | 1723 | No protein | - | An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron | - | - | - | |
| ENST00000471383.1 | CASP8-015 | 969 | No protein | - | An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron | - | - | - |
