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Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
- GO: Cellular component
- GO: Molecular function
- GO: Biological process
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
External references
Supporting evidence
ID History
- Gene history

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Gene: SIRT6 ENSG00000077463

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Description

sirtuin 6 [Source:HGNC Symbol;Acc:14934]

Gene Synonyms

SIR2L6

Location

Chromosome 19: 4,174,106-4,182,601 reverse strand.

GRCh37:CM000681.1

About this gene

This gene has 16 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 1 phenotype.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000337491.2	SIRT6-001	1641	355aa	ENSP00000337332.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS12122	B4DDV3 Q8N6T7	NM_016539.2	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000594279.1	SIRT6-008	1507	176aa	ENSP00000472023.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		M0R1N9	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000305232.6	SIRT6-002	1506	328aa	ENSP00000305310.5	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS54199	Q8N6T7	NM_001193285.1	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000381935.3	SIRT6-201	1473	283aa	ENSP00000371360.3	Gene/transcipt that contains an open reading frame (ORF).Protein coding		B4DDV3	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000601488.1	SIRT6-006	1361	187aa	ENSP00000469001.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		M0QXA0	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000597896.1	SIRT6-011	827	275aa	ENSP00000470215.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		M0QZ09	-	5' and 3' truncations in transcript evidence prevent annotation of the start and the end of the CDS.CDS 5' and 3' incomplete,
ENST00000601571.1	SIRT6-015	716	186aa	ENSP00000471837.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		M0R1F6	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000600938.1	SIRT6-009	1473	43aa	ENSP00000471123.1	Nonsense mediated decay		M0R0B2	-	-
ENST00000599365.1	SIRT6-007	1372	43aa	ENSP00000473085.1	Nonsense mediated decay		M0R0B2	-	-
ENST00000596119.1	SIRT6-004	1537	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000600540.1	SIRT6-005	1407	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000601069.1	SIRT6-003	1260	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000595670.1	SIRT6-010	1057	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000596298.1	SIRT6-013	717	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000599394.1	SIRT6-014	607	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000594341.1	SIRT6-012	371	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Summary

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