Gene: MLKL ENSG00000168404

Description

mixed lineage kinase domain-like [Source:HGNC Symbol;Acc:26617]

Gene Synonyms

FLJ34389

Location

Chromosome 16: 74,705,753-74,734,858 reverse strand.

GRCh37:CM000678.1

About this gene

This gene has 8 transcripts (splice variants).

Transcripts

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Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000308807.7	MLKL-001	2523	471aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS32487	I3L2T9 I3L4Z5 Q8NB16	NM_152649.2	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000306247.7	MLKL-002	1781	263aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS45528	I3L4Z5 Q8NB16	NM_001142497.1	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000573267.1	MLKL-005	1004	211aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		I3L2T9 I3L4Z5	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000575686.1	MLKL-006	567	62aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		I3L4Z5	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000576529.1	MLKL-008	458	102aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000571303.1	MLKL-007	781	175aa	Nonsense mediated decay		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000570846.1	MLKL-003	3882	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000575695.1	MLKL-004	2566	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

Summary

Name

MLKL (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: Q8NB16

CCDS

This gene is a member of the Human CCDS set: CCDS32487.1, CCDS45528.1

Ensembl version

ENSG00000168404.8

Other assemblies

This gene maps to 74,671,855-74,700,960 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000177356 (version 4)

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Gene: MLKL ENSG00000168404

Summary