Gene: LRRK2 ENSG00000188906

Description

leucine-rich repeat kinase 2 [Source:HGNC Symbol;Acc:18618]

Gene Synonyms

AURA17, DARDARIN, DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2

Location

Chromosome 12: 40,590,546-40,763,087 forward strand.

GRCh37:CM000674.1

About this gene

This gene has 7 transcripts (splice variants), 1 paralogue and is associated with 4 phenotypes.

Transcripts

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Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000298910.7	LRRK2-004	9158	2527aa	ENSP00000298910.7	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS31774	Q5S007	NM_198578.3	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000343742.2	LRRK2-002	4740	1271aa	ENSP00000341930.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding		A2VED2 E9PC85	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000416796.1	LRRK2-001	1655	521aa	ENSP00000398726.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		C9JBF0	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000430804.1	LRRK2-005	6400	207aa	ENSP00000410821.1	Nonsense mediated decay		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000481256.1	LRRK2-007	561	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000479187.1	LRRK2-003	8306	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000474202.1	LRRK2-006	556	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Gene: LRRK2 ENSG00000188906

Summary