Gene: NOS3 ENSG00000164867

Description

nitric oxide synthase 3 (endothelial cell) [Source:HGNC Symbol;Acc:7876]

Gene Synonyms

ECNOS, eNOS

Location

Chromosome 7: 150,688,083-150,711,676 forward strand.

GRCh37:CM000669.1

About this gene

This gene has 10 transcripts (splice variants), 4 paralogues and is associated with 1 phenotype.

Transcripts

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Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000297494.3	NOS3-001	4388	1203aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS5912	E7ESA7 O14937 P29474 Q96J98 Q96P37	NM_000603.4	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000461406.1	NOS3-002	3644	997aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E7ESA7 Q96P37	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000484524.1	NOS3-004	2537	629aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS55182	O14937 P29474 Q96J98 Q96P37	NM_001160111.1	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000467517.1	NOS3-005	2377	614aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS55183	O14937 Q96J98 Q96P37	NM_001160110.1	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000475017.1	NOS3-006	1143	306aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000477227.1	NOS3-011	1111	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000468293.1	NOS3-010	737	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000473057.1	NOS3-009	441	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000460603.1	NOS3-008	332	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000475454.1	NOS3-013	366	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

Summary

Name

NOS3 (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: P29474

CCDS

This gene is a member of the Human CCDS set: CCDS55182.1, CCDS55183.1, CCDS5912.1

Ensembl version

ENSG00000164867.6

Other assemblies

This gene maps to 150,990,995-151,014,588 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000158343 (version 4)

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Gene: NOS3 ENSG00000164867

Summary