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Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: TOPBP1 ENSG00000163781

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Description

topoisomerase (DNA) II binding protein 1 [Source:HGNC Symbol;Acc:17008]

Gene Synonyms

KIAA0259, TOP2BP1

Location

Chromosome 3: 133,317,019-133,380,737 reverse strand.

GRCh37:CM000665.1

About this gene

This gene has 10 transcripts (splice variants) and 1 paralogue.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000260810.5	TOPBP1-001	5378	1522aa	ENSP00000260810.5	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS46919	A0AV47 Q92547	NM_007027.3	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic,
ENST00000508524.1	TOPBP1-003	618	206aa	ENSP00000421179.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		-	-	5' and 3' truncations in transcript evidence prevent annotation of the start and the end of the CDS.CDS 5' and 3' incomplete,
ENST00000572787.1	TOPBP1-011	402	50aa	ENSP00000458790.1	Nonsense mediated decay		I3L1F2	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000511439.1	TOPBP1-004	1142	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000503338.1	TOPBP1-007	618	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000503464.1	TOPBP1-008	525	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000513818.1	TOPBP1-002	898	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000509162.1	TOPBP1-005	811	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000506779.1	TOPBP1-009	536	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000505804.1	TOPBP1-010	472	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Summary

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