Gene: APOE ENSG00000130203

Description

apolipoprotein E [Source:HGNC Symbol;Acc:613]

Gene Synonyms

AD2, LDLCQ5, LPG

Location

Chromosome 19: 45,409,011-45,412,650 forward strand.

GRCh37:CM000681.1

About this gene

This gene has 5 transcripts (splice variants) and is associated with 11 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000252486.4	APOE-001	1208	317aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS12647	E7ERP7 E9PEV4 J9ZVQ3 P02649 Q6LA97 Q6LBZ1	NM_000041.2	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000425718.1	APOE-005	923	219aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E7ERP7 E9PEV4 Q6LA97	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000434152.1	APOE-004	864	269aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E7ERP7 E9PEV4 H0Y7L5 Q6LA97 Q6LBZ1	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000446996.1	APOE-002	737	216aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E9PEV4 Q6LA97	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000485628.2	APOE-003	771	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

Summary

Name

APOE (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: P02649

CCDS

This gene is a member of the Human CCDS set: CCDS12647.1

Ensembl version

ENSG00000130203.5

Other assemblies

This gene maps to 44,905,754-44,909,393 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000128901 (version 3)

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Gene: APOE ENSG00000130203

Summary