Gene: GCK ENSG00000106633

Description

glucokinase (hexokinase 4) [Source:HGNC Symbol;Acc:4195]

Gene Synonyms

FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2

Location

Chromosome 7: 44,183,872-44,237,769 reverse strand.

GRCh37:CM000669.1

About this gene

This gene has 8 transcripts (splice variants), 4 paralogues and is associated with 6 phenotypes.

Transcripts

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Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000345378.2	GCK-002	2421	466aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS5480	M4PPE1 M4PS83 P35557	NM_033507.1	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000403799.3	GCK-001	2729	465aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS5479	M4PPE1 M4PS83 P35557 Q53Y25	NM_000162.3	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000395796.3	GCK-003	2539	464aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS5481	M4PPE1 M4PS83 P35557	NM_033508.1	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000437084.1	GCK-004	1385	448aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		C9JQD1 M4PPE1 M4PS83	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000336642.4	GCK-006	1311	149aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		H7BXV0 M4PPE1	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000476008.1	GCK-008	553	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000473353.1	GCK-007	404	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000459642.1	GCK-005	1641	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

Summary

Name

GCK (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: P35557

CCDS

This gene is a member of the Human CCDS set: CCDS5479.1, CCDS5480.1, CCDS5481.1

Ensembl version

ENSG00000106633.11

Other assemblies

This gene maps to 44,144,273-44,198,170 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000022903 (version 4)

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Gene: GCK ENSG00000106633

Summary