Gene: CD74 ENSG00000019582

Description

CD74 molecule, major histocompatibility complex, class II invariant chain [Source:HGNC Symbol;Acc:1697]

Gene Synonyms

DHLAG, HLADG, II, Ia-GAMMA

Location

Chromosome 5: 149,781,200-149,792,492 reverse strand.

GRCh37:CM000667.1

About this gene

This gene has 12 transcripts (splice variants) and is associated with 46 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000009530.7	CD74-003	981	296aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS47309	O19685 O78208 P04233	-	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000518797.1	CD74-004	1727	316aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		O78208	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000353334.6	CD74-001	1449	232aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS47308	O19685 P04233	NM_004355.3	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000377795.3	CD74-002	1138	160aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS34276	O19685 P04233	NM_001025158.2	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000524315.1	CD74-011	584	152aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E7ESL3 O19685	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000523208.1	CD74-008	767	145aa	Nonsense mediated decay		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000522246.1	CD74-009	563	122aa	Nonsense mediated decay		E7EQJ3 O19685	-	-
ENST00000523813.1	CD74-007	546	52aa	Nonsense mediated decay		E7ER71 O19685	-	-
ENST00000517791.1	CD74-005	1015	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000517752.1	CD74-013	816	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000523836.1	CD74-006	724	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000522153.1	CD74-010	556	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

Summary

Name

CD74 (HGNC Symbol)

UniProtKB

This gene has proteins that correspond to the following UniProtKB identifiers: P04233

CCDS

This gene is a member of the Human CCDS set: CCDS34276.1, CCDS47308.1, CCDS47309.1

Ensembl version

ENSG00000019582.10

Other assemblies

This gene maps to 150,401,637-150,412,929 in GRCh38 coordinates.

Gene type

Protein coding

Annotation method

Annotation for this gene includes both automatic annotation from Ensembl and Havana manual curation, see article.

Alternative genes

This gene corresponds to the following database identifiers:

Havana gene:	OTTHUMG00000163559 (version 3)

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Gene: CD74 ENSG00000019582

Summary