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Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
- GO: Anatomical entity
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
External references
Supporting evidence
ID History
- Gene history

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Gene: APH1B ENSG00000138613

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Description

APH1B gamma secretase subunit [Source:HGNC Symbol;Acc:24080]

Gene Synonyms

APH-1B, APH1B, DKFZp564D0372, PRO1328, PSFL, TAAV688

Location

Chromosome 15: 63,568,217-63,601,325 forward strand.

GRCh37:CM000677.1

About this gene

This gene has 10 transcripts (splice variants), 188 orthologues and 1 paralogue.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000261879.5	APH1B-001	4189	257aa	ENSP00000261879.5	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS10184	H0YKZ9 Q8WW43	NM_031301.3	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000560890.1	APH1B-006	758	188aa	ENSP00000453002.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		H0YKZ9	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000380343.4	APH1B-002	685	216aa	ENSP00000369700.4	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS45276	Q8WW43	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000560353.1	APH1B-005	672	222aa	ENSP00000453327.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		H0YLT0	-	3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENST00000559971.1	APH1B-004	1455	19aa	ENSP00000453516.1	Nonsense mediated decay		-	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000380340.4	APH1B-003	872	81aa	ENSP00000369697.4	Nonsense mediated decay		Q4R1J8	-	-
ENST00000560716.1	APH1B-008	731	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000559744.1	APH1B-010	456	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000559823.1	APH1B-009	376	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000558631.1	APH1B-007	515	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Summary

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