Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: ADRBK1 ENSG00000173020

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Description

adrenergic, beta, receptor kinase 1 [Source:HGNC Symbol;Acc:289]

Gene Synonyms

BARK, BARK1, BETA-ARK1, GRK2

Location

Chromosome 11: 67,033,881-67,054,027 forward strand.

GRCh37:CM000673.1

About this gene

This gene has 14 transcripts (splice variants) and 15 paralogues.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000308595.5	ADRBK1-001	3466	689aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS8156	P25098	NM_001619.3	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000526285.1	ADRBK1-011	1458	408aa	Gene/transcipt that contains an open reading frame (ORF).Protein coding		E9PRV7	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,
ENST00000527176.1	ADRBK1-008	970	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000532099.1	ADRBK1-006	886	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000524899.1	ADRBK1-007	751	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000531390.1	ADRBK1-005	524	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000529738.1	ADRBK1-004	500	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000534651.1	ADRBK1-013	424	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000532611.1	ADRBK1-009	410	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000530291.1	ADRBK1-010	324	No protein	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000416281.2	ADRBK1-002	4493	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000533077.1	ADRBK1-003	3453	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000526572.1	ADRBK1-014	789	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000529815.1	ADRBK1-012	589	No protein	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Paralogues

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Download paralogues

Type	Ancestral taxonomy	Ensembl identifier & gene name	Compare	Location	Percentage of the paralogous sequence matching the query sequenceTarget %id	Percentage of the query sequence matching the sequence of the paralogueQuery %id
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000101049 SGK2 serum/glucocorticoid regulated kinase 2 [Source:HGNC Symbol;Acc:13900]	Alignment (protein) Alignment (cDNA)	20:42,187,608-42,216,877:1	27.00 %	17.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000270024 C8orf44-SGK3 C8orf44-SGK3 readthrough [Source:HGNC Symbol;Acc:48354]	Alignment (protein) Alignment (cDNA)	8:67,579,831-67,772,707:1	26.00 %	18.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000104205 SGK3 serum/glucocorticoid regulated kinase family, member 3 [Source:HGNC Symbol;Acc:10812]	Alignment (protein) Alignment (cDNA)	8:67,624,653-67,774,257:1	26.00 %	18.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000118515 SGK1 serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:10810]	Alignment (protein) Alignment (cDNA)	6:134,490,384-134,639,250:-1	24.00 %	18.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000117020 AKT3 v-akt murine thymoma viral oncogene homolog 3 [Source:HGNC Symbol;Acc:393]	Alignment (protein) Alignment (cDNA)	1:243,651,535-244,014,381:-1	24.00 %	17.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1 [Source:HGNC Symbol;Acc:391]	Alignment (protein) Alignment (cDNA)	14:105,235,686-105,262,088:-1	25.00 %	17.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000175634 RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Source:HGNC Symbol;Acc:10437]	Alignment (protein) Alignment (cDNA)	11:67,195,931-67,202,872:1	26.00 %	18.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000105221 AKT2 v-akt murine thymoma viral oncogene homolog 2 [Source:HGNC Symbol;Acc:392]	Alignment (protein) Alignment (cDNA)	19:40,736,224-40,791,443:-1	26.00 %	18.00 %
Ancient paralogues	Last common ancestor with S.cerevisiae (Saccharomyces cerevisiae)Animals and Fungi (Opisthokonta)	ENSG00000108443 RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Source:HGNC Symbol;Acc:10436]	Alignment (protein) Alignment (cDNA)	17:57,970,447-58,027,925:1	26.00 %	19.00 %
Ancient paralogues	Last common ancestor with Arthropods and nematodes (Ecdysozoa)Bilateral animals (Bilateria)	ENSG00000125388 GRK4 G protein-coupled receptor kinase 4 [Source:HGNC Symbol;Acc:4543]	Alignment (protein) Alignment (cDNA)	4:2,965,335-3,042,474:1	34.00 %	29.00 %
Ancient paralogues	Last common ancestor with Arthropods and nematodes (Ecdysozoa)Bilateral animals (Bilateria)	ENSG00000198873 GRK5 G protein-coupled receptor kinase 5 [Source:HGNC Symbol;Acc:4544]	Alignment (protein) Alignment (cDNA)	10:120,967,101-121,215,131:1	34.00 %	29.00 %
Ancient paralogues	Last common ancestor with Arthropods and nematodes (Ecdysozoa)Bilateral animals (Bilateria)	ENSG00000198055 GRK6 G protein-coupled receptor kinase 6 [Source:HGNC Symbol;Acc:4545]	Alignment (protein) Alignment (cDNA)	5:176,830,205-176,869,902:1	35.00 %	30.00 %
Genes (homologues) that have evolved by duplication.Paralogues	Last common ancestor with Reptiles and birds (Sauria)Amniotes (Amniota)	ENSG00000100077 ADRBK2 adrenergic, beta, receptor kinase 2 [Source:HGNC Symbol;Acc:290]	Alignment (protein) Alignment (cDNA)	22:25,960,816-26,125,261:1	84.00 %	84.00 %
Genes (homologues) that have evolved by duplication.Paralogues	Last common ancestor with Ciona sea squirts (Ciona)Chordates (Chordata)	ENSG00000185974 GRK1 G protein-coupled receptor kinase 1 [Source:HGNC Symbol;Acc:10013]	Alignment (protein) Alignment (cDNA)	13:114,321,470-114,440,708:1	33.00 %	27.00 %
Genes (homologues) that have evolved by duplication.Paralogues	Last common ancestor with Ciona sea squirts (Ciona)Chordates (Chordata)	ENSG00000114124 GRK7 G protein-coupled receptor kinase 7 [Source:HGNC Symbol;Acc:17031]	Alignment (protein) Alignment (cDNA)	3:141,496,990-141,537,332:1	31.00 %	25.00 %

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