How is Ensembl regulatory annotation generated?
Regulatory annotations for release 116 are based primarily on ChIP-seq, DNase-seq, and ATAC-seq data generated by the ENCODE and FAANG consortia, and gene annotation from Ensembl/GENCODE.
The Ensembl regulatory build annotates genomic regions that have primary data supporting a potential non-coding regulatory function as regulatory features.
For each cell type (epigenome) regulatory features are assigned labels to describe their activity levels. These include:
- ACTIVE, when the feature overlaps an open chromatin peak in the corresponding epigenome,
- INACTIVE, when there is no corresponding open chromatin peak,
- You can learn more about the Ensembl Regulation pipelines here
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