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Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: TOPBP1 ENSG00000163781

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Description

topoisomerase (DNA) II binding protein 1 [Source:HGNC Symbol;Acc:17008]

Gene Synonyms

KIAA0259, TOP2BP1

Location

Chromosome 3: 133,317,019-133,380,737 reverse strand.

GRCh37:CM000665.1

About this gene

This gene has 10 transcripts (splice variants) and 1 paralogue.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq	Flags
ENST00000260810.5	TOPBP1-001	5378	1522aa	ENSP00000260810.5	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS46919	A0AV47 Q92547	NM_007027.3	The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic,
ENST00000508524.1	TOPBP1-003	618	206aa	ENSP00000421179.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		-	-	5' and 3' truncations in transcript evidence prevent annotation of the start and the end of the CDS.CDS 5' and 3' incomplete,
ENST00000572787.1	TOPBP1-011	402	50aa	ENSP00000458790.1	Nonsense mediated decay		I3L1F2	-	5' truncation in transcript evidence prevents annotation of the start of the CDS.CDS 5' incomplete,
ENST00000511439.1	TOPBP1-004	1142	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000503338.1	TOPBP1-007	618	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000503464.1	TOPBP1-008	525	No protein	-	Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript		-	-	-
ENST00000513818.1	TOPBP1-002	898	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000509162.1	TOPBP1-005	811	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000506779.1	TOPBP1-009	536	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-
ENST00000505804.1	TOPBP1-010	472	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	-

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Summary

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