Description
MDM2 oncogene, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:6973]
Gene Synonyms
ACTFS, HDM2, HDMX, MDM2, MGC5370, hdm2
Location
Chromosome 12: 69,201,956-69,239,214 forward strand.
GRCh37:CM000674.1
About this gene
This gene has 37 transcripts (splice variants), 1 paralogue and is associated with 76 phenotypes.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | CCDS | UniProt Match | RefSeq | Flags |
|---|---|---|---|---|---|---|---|---|---|
| ENST00000462284.1 | MDM2-001 | 7381 | 497aa | ENSP00000417281.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS8986 | A7UKY0 A8WFP2 Q00987 Q546E6 | NM_002392.5 | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, |
| ENST00000258149.5 | MDM2-201 | 7198 | 436aa | ENSP00000258149.5 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | NM_001145339.2 | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000356290.4 | MDM2-202 | 6853 | 321aa | ENSP00000348637.4 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS61189 | E7EMW5 Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, |
| ENST00000540827.1 | MDM2-205 | 6778 | 296aa | ENSP00000440932.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000428863.2 | MDM2-204 | 6700 | 270aa | ENSP00000410694.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000350057.5 | MDM2-033 | 1401 | 466aa | ENSP00000266624.9 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | J3KN53 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000258148.7 | MDM2-003 | 1361 | 442aa | ENSP00000258148.7 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | G3XA89 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000393412.3 | MDM2-203 | 1171 | 218aa | ENSP00000377064.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000299252.4 | MDM2-006 | 966 | 321aa | ENSP00000299252.4 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | CCDS61189 | E7EMW5 Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, |
| ENST00000360430.2 | MDM2-008 | 891 | 296aa | ENSP00000353611.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000539479.1 | MDM2-012 | 845 | 257aa | ENSP00000444430.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | A7UKY0 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000393415.3 | MDM2-022 | 842 | 256aa | ENSP00000377067.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | A7UKX8 | NM_001145337.2 | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000348801.2 | MDM2-009 | 798 | 265aa | ENSP00000335096.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000393416.2 | MDM2-013 | 754 | 229aa | ENSP00000377068.2 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EPE2 | - | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000393410.1 | MDM2-004 | 732 | 243aa | ENSP00000377062.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q546E6 Q9H4C5 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000478070.1 | MDM2-011 | 692 | 49aa | ENSP00000430906.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E5RHE2 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000393413.3 | MDM2-032 | 657 | 218aa | ENSP00000377065.3 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | Q00987 Q546E6 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000523991.1 | MDM2-016 | 505 | 143aa | ENSP00000427828.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | E7EMW5 | NM_001278462.1 | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000543323.1 | MDM2-023 | 427 | 117aa | ENSP00000439238.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | A7UKX7 | NM_001145340.2 | 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete, | |
| ENST00000545204.1 | MDM2-024 | 398 | 51aa | ENSP00000444597.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | F5GZB0 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000517852.1 | MDM2-019 | 393 | 130aa | ENSP00000430257.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | I6SST1 I6TMT6 I6TZT0 Q9H4C3 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000544561.1 | MDM2-026 | 213 | 70aa | ENSP00000441841.1 | Gene/transcipt that contains an open reading frame (ORF).Protein coding | F5GWH7 | - | The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, | |
| ENST00000393417.3 | MDM2-002 | 1683 | 70aa | ENSP00000429021.2 | Nonsense mediated decay | Q8NDW1 | - | - | |
| ENST00000311420.9 | MDM2-010 | 1583 | 84aa | ENSP00000310742.9 | Nonsense mediated decay | F5H1M7 J3QST1 | - | - | |
| ENST00000540352.1 | MDM2-028 | 1315 | 170aa | ENSP00000445030.1 | Nonsense mediated decay | F5H4Q8 | - | - | |
| ENST00000536089.1 | MDM2-031 | 1181 | 78aa | ENSP00000444028.1 | Nonsense mediated decay | F5H1M7 | - | - | |
| ENST00000542502.1 | MDM2-029 | 1127 | 84aa | ENSP00000444566.1 | Nonsense mediated decay | F5GZC3 | - | - | |
| ENST00000481186.1 | MDM2-007 | 1056 | 35aa | ENSP00000431110.1 | Nonsense mediated decay | E5RJQ0 | - | - | |
| ENST00000537182.1 | MDM2-030 | 1011 | 78aa | ENSP00000443450.1 | Nonsense mediated decay | F5H1M7 | - | - | |
| ENST00000496959.1 | MDM2-005 | 897 | 60aa | ENSP00000429692.1 | Nonsense mediated decay | Q96DS5 | - | - | |
| ENST00000546048.1 | MDM2-027 | 363 | 78aa | ENSP00000445222.1 | Nonsense mediated decay | F5H1M7 | - | - | |
| ENST00000544125.1 | MDM2-043 | 649 | No protein | - | Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript | - | - | - | |
| ENST00000540709.1 | MDM2-042 | 502 | No protein | - | Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript | - | - | - | |
| ENST00000400501.2 | MDM2-044 | 406 | No protein | - | Gene/transcript that doesn't contain an open reading frame (ORF).Processed transcript | - | - | - | |
| ENST00000493419.1 | MDM2-015 | 577 | No protein | - | An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron | - | - | - | |
| ENST00000543046.1 | MDM2-041 | 432 | No protein | - | An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron | - | - | - | |
| ENST00000471946.1 | MDM2-014 | 251 | No protein | - | An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron | - | - | - |
